Article
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.
Nature - 14 Aug 2003
Trompouki Eirini, Hatzivassiliou Eudoxia, Tsichritzis Theodore, Farmer Hannah, Ashworth Alan, Mosialos George
Abstract excerpt
Familial cylindromatosis is an autosomal dominant predisposition to tumours of skin appendages called cylindromas. Familial cylindromatosis is caused by mutations in a gene encoding the CYLD protein of previously unknown function. Here we show that CYLD is a deubiquitinating enzyme that negatively regulates activation of the transcription factor NF-kappaB by specific tumour-necrosis factor receptors (TNFRs). Loss...
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