Article

Caspase-8-mediated CYLD Cleavage boosts LPS-induced Endotoxic Shock

2024-04-04

Abstract excerpt

Caspase-8, a pivotal protease intricately involved in various cellular signaling pathways related to cell death and inflammation, has been identified as a contributor to cytokine production during septic shock. However, the mechanisms governing this regulatory role remain enigmatic. In this study, we uncovered that mice harboring a specific mutation in CYLD at its D215 position ( Cyld D 215 A/D 215 A mutant mice...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0dca7022-4dc5-5ec7-a3d9-7a5005b69cca
DOI: 10.1101/2024.04.03.587858

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Caspase-8-mediated CYLD Cleavage boosts LPS-induced Endotoxic ShockDOI 10.1101/2024.04.03.587858Read

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis.Semantic proximity Read

The Role of the Key Effector of Necroptotic Cell Death, Mlkl, in Mouse Models of DiseaseSemantic proximity Read

Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and diseaseSemantic proximity Read

The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of DiseaseSemantic proximity Read

Caspase-11 Non-Canonical Inflammasome: Emerging Activator and Regulator of Infection-Mediated Inflammatory ResponsesSemantic proximity Read

CYLD-Mediated Signaling and DiseasesSemantic proximity Read

Cyld aborts hyperactivation of synovial fibroblasts in inflammatory arthritis by regulating the TAK1/IKK2 signaling axisSemantic proximity Read

Immune dysregulation in SHARPIN-deficient mice is dependent on CYLD-mediated cell deathSemantic proximity Read

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implicationsSemantic proximity Read

The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathologySemantic proximity Read

The zebrafish NLRP3 inflammasome has functional roles in ASC-dependent interleukin-1β maturation and gasdermin E–mediated pyroptosisSemantic proximity Read

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.Semantic proximity Read