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Article

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.

Nature - 14 Aug 2003

Kovalenko Andrew, Chable-Bessia Christine, Cantarella Giuseppina, Israël Alain, Wallach David, Courtois Gilles

Abstract excerpt

NF-kappaB transcription factors have key roles in inflammation, immune response, oncogenesis and protection against apoptosis. In most cells, these factors are kept inactive in the cytoplasm through association with IkappaB inhibitors. After stimulation by various reagents, IkappaB is phosphorylated by the IkappaB kinase (IKK) complex and degraded by the proteasome, allowing NF-kappaB to translocate to the...

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Source

Identifiers

PMID: 12917691
DOI: 10.1038/nature01802

Genes

CYLD
TNF
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.PMID 12917691Read ↗

CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members.Semantic proximity Read ↗

NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway.Semantic proximity Read ↗

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice.Semantic proximity Read ↗

The Tumor Suppressor CYLD Interacts with TRIP and Regulates Negatively Nuclear Factor κB Activation by Tumor Necrosis FactorSemantic proximity Read ↗

Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation.Semantic proximity Read ↗

CYLD-Mediated Signaling and DiseasesSemantic proximity Read ↗

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin.Semantic proximity Read ↗

Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells.Semantic proximity Read ↗

MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomasSemantic proximity Read ↗

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.Semantic proximity Read ↗

Tumor Suppressor Function of CYLD in Nonmelanoma Skin CancerSemantic proximity Read ↗

The cylindromatosis gene product, CYLD, interacts with MIB2 to regulate Notch signallingSemantic proximity Read ↗

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