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Article

Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.

The Journal of experimental medicine - 29 Oct 2007

Hövelmeyer Nadine, Wunderlich F Thomas, Massoumi Ramin, Jakobsen Charlotte G, Song Jian, Wörns Marcus A, Merkwirth Carsten, Kovalenko Andrew, Aumailley Monique, Strand Dennis, Brüning Jens C, Galle Peter R, Wallach David, Fässler Reinhard, Waisman Ari

Abstract excerpt

B cell homeostasis is regulated by multiple signaling processes, including nuclear factor-kappaB (NF-kappaB), BAFF-, and B cell receptor signaling. Conditional disruption of genes involved in these pathways has shed light on the mechanisms governing signaling from the cell surface to the nucleus. We describe a novel mouse strain that expresses solely and excessively a naturally occurring splice variant of CYLD...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17923499
DOI: 10.1084/jem.20070318
PMCID: PMC2118471

Genes

CYLD
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.PMID 17923499Read ↗

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