Article

Mosaic deletion patterns of the human antibody heavy chain gene locus as revealed by Bayesian haplotyping

2018-05-04

Abstract excerpt

Analysis of antibody repertoires by high-throughput sequencing is of major importance in understanding adaptive immune responses. Our knowledge of variations in the genomic loci encoding antibody genes is incomplete, mostly due to technical difficulties in aligning short reads to these highly repetitive loci. The partial knowledge results in conflicting V-D-J gene assignments between different algorithms, and bia...

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Literature Corpus work: 04ad9005-f7fe-5cc9-8f22-1d743f48f38a
DOI: 10.1101/314476

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