Article

T2T-CHM13 vs GRCh38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ethnicity

2023-05-25

Abstract excerpt

Antibody production by B-cells is essential for protective immunity. The clonal selection theory posits that each mature B cell has a unique immunoglobulin receptor generated through random gene recombination and, when stimulated to differentiate into an antibody-secreting cell, has the capacity to produce only a single antibody specificity. It follows from this “one-cell-one-antibody” dogma, that single-cell RNA-...

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Literature Corpus work: 74d1bc16-5cbc-5aed-9f3b-98c855d8f9ee
DOI: 10.1101/2023.05.24.542206

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T2T-CHM13 vs GRCh38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ethnicityDOI 10.1101/2023.05.24.542206Read

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