Article

Attenuation of HIV severity by slightly deleterious mutations can explain the long-term trajectory of virulence evolution

2025-05-15

Abstract excerpt

HIV-1 is a well-studied example of a pathogen that has evolved an intermediate level of virulence that maximises transmission. For a trait to evolve it must be heritable, and although viral load—a proxy for disease severity—has been shown to be a heritable trait, it is surprising that specific heritable viral factors remain mostly elusive. Rapid within-host evolution is also expected to diminish heritability. We h...

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Literature Corpus work: 8378e20f-55cf-52ad-b6a6-2fafc1641115
DOI: 10.1101/2025.05.12.653435

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