Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity.

doi:10.1093/molbev/msx246

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Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity.

Molecular biology and evolution - 1 Jan 2018

Bertels Frederic, Marzel Alex, Leventhal Gabriel, Mitov Venelin, Fellay Jacques, Günthard Huldrych F, Böni Jürg, Yerly Sabine, Klimkait Thomas, Aubert Vincent, Battegay Manuel, Rauch Andri, Cavassini Matthias, Calmy Alexandra, Bernasconi Enos, Schmid Patrick, Scherrer Alexandra U, Müller Viktor, Bonhoeffer Sebastian, Kouyos Roger, Regoes Roland R

Abstract excerpt

Pathogen strains may differ in virulence because they attain different loads in their hosts, or because they induce different disease-causing mechanisms independent of their load. In evolutionary ecology, the latter is referred to as "per-parasite pathogenicity". Using viral load and CD4+ T-cell measures from 2014 HIV-1 subtype B-infected individuals enrolled in the Swiss HIV Cohort Study, we investigated if...

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PMID: 29029206
DOI: 10.1093/molbev/msx246
PMCID: PMC5850767

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