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Article

Attenuation of HIV severity by slightly deleterious mutations can explain the long-term trajectory of virulence evolution.

PLoS computational biology - 1 Dec 2025

Longley Harriet, Fraser Christophe, Wymant Chris, Lythgoe Katrina

Abstract excerpt

HIV-1 is a well-studied example of a pathogen that has evolved an intermediate level of virulence that maximises transmission. For a trait to evolve it must be heritable, and although viral load-a proxy for disease severity-has been shown to be a heritable trait, it is surprising that specific heritable viral factors remain mostly elusive. Rapid within-host evolution is also expected to diminish heritability. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41325373
DOI: 10.1371/journal.pcbi.1013131
PMCID: PMC12677797

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