Article

Evolution of HIV virulence in response to widespread scale up of antiretroviral therapy: a modeling study

2016-02-21

Abstract excerpt

There are global increases in the use of HIV antiretroviral therapy (ART), guided by clinical benefits of early ART initiation, and the efficacy of treatment as prevention of transmission. Separately, it has been shown theoretically and empirically that HIV virulence can evolve over time. Observed virulence levels may reflect an adaptive balance between infected lifespan and per-contact transmission rate. Critical...

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Literature Corpus work: 1359d31a-118e-541a-a365-f1ff2b77e31c
DOI: 10.1101/039560

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