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A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

5 Nov 2016

Abstract excerpt

Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as a result of a trade-off between virulence and transmission, but empirical evidence remains scarce. We bridge this gap using data from a large and long-standing HIV-1 prospective cohort, in Uganda. We use an epidemiological-evolutionary model parameterised with this data to derive evolutionary predictions based on analysis...

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PMID: 27815945
DOI: 10.7554/elife.20492

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