Article

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in <i>Betacoronavirus</i> replication

2021-05-17

Abstract excerpt

As coronaviruses (CoVs) replicate in the host cell cytoplasm, they rely on their own capping machinery to ensure the efficient translation of their mRNAs, protect them from degradation by cellular 5’ exoribonucleases, and escape innate immune sensing. The CoV nonstructural protein 14 (nsp14) is a bi-functional replicase subunit harboring an N-terminal 3′-to-5′ exoribonuclease (ExoN) domain and a C-terminal (N7-gua...

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Literature Corpus work: 83543fa6-7c9b-5759-a827-658902af03b7
DOI: 10.1101/2021.05.17.444407

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Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in <i>Betacoronavirus</i> replicationDOI 10.1101/2021.05.17.444407Read

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