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Article

Porcine Epidemic Diarrhea Virus Deficient in RNA Cap Guanine-N-7 Methylation Is Attenuated and Induces Higher Type I and III Interferon Responses.

Journal of virology - 30 Jul 2020

Lu Yunjian, Cai Hui, Lu Mijia, Ma Yuanmei, Li Anzhong, Gao Youling, Zhou Jiyong, Gu Howard, Li Jianrong, Gu Jinyan

Abstract excerpt

The 5' cap methylation of viral RNA plays important roles in RNA stability, efficient translation, and immune evasion. Thus, RNA cap methylation is an attractive target for antiviral discovery and development of new live attenuated vaccines. For coronaviruses, RNA cap structure is first methylated at the guanine-N-7 (G-N-7) position by nonstructural protein 14 (nsp14), which facilitates and precedes the...

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Identifiers

PMID: 32461321
DOI: 10.1128/JVI.00447-20
PMCID: PMC7394890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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