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The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity.

Journal of virology - 25 Feb 2025

Grimes Samantha L, Heaton Brook E, Anderson Mackenzie L, Burke Katie, Stevens Laura, Lu Xiaotao, Heaton Nicholas S, Denison Mark R, Anderson-Daniels Jordan

Abstract excerpt

Coronaviruses (CoVs) encode non-structural proteins (nsp's) 1-16, which assemble to form replication-transcription complexes that function in viral RNA synthesis. All CoVs encode a proofreading 3'-5' exoribonuclease in non-structural protein 14 (nsp14-ExoN) that mediates proofreading and high-fidelity replication and is critical for other roles in replication and pathogenesis. The in vitro enzymatic activity of...

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Identifiers

PMID: 39791922
DOI: 10.1128/jvi.01708-24
PMCID: PMC11852845

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