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Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

9 Jul 2015

Abstract excerpt

Nonstructural protein 14 (nsp14) of coronaviruses (CoV) is important for viral replication and transcription. The N-terminal exoribonuclease (ExoN) domain plays a proofreading role for prevention of lethal mutagenesis, and the C-terminal domain functions as a (guanine-N7) methyl transferase (N7-MTase) for mRNA capping. The molecular basis of both these functions is unknown. Here, we describe crystal structures of...

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PMID: 26159422
DOI: 10.1073/pnas.1508686112

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