Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009

Chen Yu, Cai Hui, Pan Ji'an, Xiang Nian, Tien Po, Ahola Tero, Guo Deyin

Abstract excerpt

The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to cap their RNAs. In this report, we used a yeast genetic system to functionally screen for the cap-f...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Deletion
Share to Genome, Viral
Share to Guanosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyltransferases

Share to Severe acute respiratory syndrome-related coronavirus

Share to Transcription, Genetic

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 19208801
DOI: 10.1073/pnas.0808790106
PMCID: PMC2651275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19208801-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.PMID 19208801Read ↗

Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replicationSemantic proximity Read ↗

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in <i>Betacoronavirus</i> replicationSemantic proximity Read ↗

Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.Semantic proximity Read ↗

The SARS-CoV-2 RNA polymerase is a viral RNA capping enzymeSemantic proximity Read ↗

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.Semantic proximity Read ↗

Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complexSemantic proximity Read ↗

Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass SpectrometrySemantic proximity Read ↗

Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assaySemantic proximity Read ↗

Flavivirus RNA methylationSemantic proximity Read ↗

Porcine Epidemic Diarrhea Virus Deficient in RNA Cap Guanine-N-7 Methylation Is Attenuated and Induces Higher Type I and III Interferon Responses.Semantic proximity Read ↗

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complexSemantic proximity Read ↗

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.