Article

The enzymatic activity of the nsp14 exoribonuclease is critical for replication of Middle East respiratory syndrome-coronavirus

2020-06-20

Abstract excerpt

<h4> A bstract </h4> Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains an N-terminal 3’-to-5’ exoribonuclease (ExoN) and a C-terminal N7-methyltransferase (N7-MTase) domain. While the latter presumably operates during viral mRNA capping, ExoN is thought to mediate proofreading during genom...

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Literature Corpus work: 6429d4ea-ed32-5c28-9214-c2b45193725b
DOI: 10.1101/2020.06.19.162529

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