Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

26 Dec 2017

Abstract excerpt

Coronaviruses (CoVs) stand out among RNA viruses because of their unusually large genomes (∼30 kb) associated with low mutation rates. CoVs code for nsp14, a bifunctional enzyme carrying RNA cap guanine N7-methyltransferase (MTase) and 3'-5' exoribonuclease (ExoN) activities. ExoN excises nucleotide mismatches at the RNA 3'-end in vitro, and its inactivation in vivo jeopardizes viral genetic stability. Here, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacteriophages and microbial interactions
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29279395
DOI: 10.1073/pnas.1718806115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNAPMID 29279395Read ↗

Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complexSemantic proximity Read ↗

Structure–function analysis of the nsp14 N7–guanine methyltransferase reveals an essential role in Betacoronavirus replicationSemantic proximity Read ↗

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in <i>Betacoronavirus</i> replicationSemantic proximity Read ↗

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complexSemantic proximity Read ↗

Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzymeSemantic proximity Read ↗

Structure and dynamics of SARS-CoV-2 proofreading exoribonuclease ExoNSemantic proximity Read ↗

Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity.Semantic proximity Read ↗

The SARS-CoV-2 RNA polymerase is a viral RNA capping enzymeSemantic proximity Read ↗

Coronaviruses: An RNA proofreading machine regulates replication fidelity and diversitySemantic proximity Read ↗

The Enzymatic Activity of the nsp14 Exoribonuclease Is Critical for Replication of MERS-CoV and SARS-CoV-2.Semantic proximity Read ↗

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites.Semantic proximity Read ↗

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.