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Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen <i>Haemophilus influenzae</i>

2025-05-07

Abstract excerpt

The evolution of antimicrobial resistant (AMR) pathogens poses a global health threat and it is unclear if evolutionary trajectories to resistance lead to predictable phenotypes. We analyzed AMR-evolution in the human pathogen Haemophilus influenzae in controlled evolution experiments with increasing concentrations of either ampicillin, cefotaxime, or ceftriaxone. We isolated 315 clones from different time points...

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Identifiers and source

Literature Corpus work
8349c4ea-67ca-542d-b7f4-aa075cf316d1
DOI
10.1101/2025.05.02.651845
Open publication

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Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen <i>Haemophilus influenzae</i>DOI 10.1101/2025.05.02.651845
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