Back to search

Article

A high-resolution genomic and phenotypic analysis of resistance evolution of an<i>Escherichia coli</i>strain from a critical care patient treated with piperacillin/tazobactam

2024-01-16

Abstract excerpt

Resistance to the β-lactam/β-lactamase inhibitor (BL/BLI) combination antibiotic piperacillin/tazobactam (TZP) predominantly occurs via β-lactamase enzymes also leading to resistance to third-generation cephalosporins (3GCs). However, if β-lactamases inactive against 3GCs and inhibited by tazobactam are expressed at high levels leading to enzyme hyperproduction, the surplus enzyme escapes inhibition by tazobactam...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
2209c9e4-b13d-53fd-9692-4f628e3d890f
DOI
10.1101/2024.01.15.24301199
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A high-resolution genomic and phenotypic analysis of resistance evolution of an<i>Escherichia coli</i>strain from a critical care patient treated with piperacillin/tazobactamDOI 10.1101/2024.01.15.24301199
Within-patient evolution to piperacillin/tazobactam resistance in a clinical isolate of <i>Escherichia coli</i> due to IS <i>26</i> -mediated amplification of <i>bla</i> <sub>TEM-1B</sub>Semantic proximity
Piperacillin/tazobactam resistant, cephalosporin susceptible <i>Escherichia coli</i> bloodstream infections are driven by multiple acquisition of resistance across diverse sequence typesSemantic proximity
Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coliSemantic proximity
Piperacillin-Tazobactam Resistance Mechanisms in <i>Escherichia coli</i> and Identification of a CTX-M-255 β-Lactamase Selectively Conferring Resistance to Penicillin/β-Lactamase Inhibitor CombinationsSemantic proximity
Genetic Determinants Underlying the Progressive Phenotype of β-lactam/β-lactamase Inhibitor Resistance in <i>Escherichia coli</i>Semantic proximity
Piperacillin/tazobactam-resistant, cephalosporin-susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse sequence typesSemantic proximity
Evolutionary trajectories of β-lactam resistance in <i>Enterococcus faecalis</i> strainsSemantic proximity
Role of blaTEM and OmpC in the piperacillin-tazobactam resistance evolution by E. coli in patients with complicated intra-abdominal infectionSemantic proximity
Piperacillin/tazobactam resistance in a clinical isolate of Escherichia coli due to IS26-mediated amplification of blaTEM-1BSemantic proximity
Genetic basis for in vivo piperacillin-tazobactam resistanceSemantic proximity
Genome-wide analysis in Escherichia coli unravels a high level of genetic homoplasy associated with cefotaxime resistance.Semantic proximity
Concurrence of Porin Loss and Modular Amplification of β-Lactamase Encoding Genes Drives Carbapenem Resistance in a Cohort of Recurrent <i>Enterobacterales</i> BacteremiaSemantic proximity
Select a neighboring publication to make it the new centre.