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Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae.

Antimicrobial agents and chemotherapy - 5 Nov 2025

Petersen Sabine, Diricks Margo, Utpatel Christian, Schulenburg Hinrich, Merker Matthias

Abstract excerpt

The evolution of antimicrobial-resistant pathogens poses a global health threat, and it is unclear if evolutionary trajectories to resistance lead to predictable phenotypes. We analyzed antimicrobial resistance (AMR) evolution in the human pathogen Haemophilus influenzae in controlled evolution experiments with increasing concentrations of either ampicillin, cefotaxime, or ceftriaxone. We isolated 315 clones from...

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Ampicillin
beta-Lactams
Cefotaxime
Ceftriaxone
Clarithromycin

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PMID: 40980920
DOI: 10.1128/aac.00576-25
PMCID: PMC12587571

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