Article

How sequence context-dependent mutability drives mutation rate variation in the genome

2021-07-21

Abstract excerpt

The rate of mutations varies >100-fold across the genome, altering the rate of evolution, and susceptibility to genetic diseases. The strongest predictor of mutation rate is the sequence itself, varying 75-fold between trinucleotides. The fact that DNA sequence drives its own mutation rate raises a simple but important prediction; highly mutable sequences will mutate more frequently and eliminate themselves in fav...

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Literature Corpus work: 83373294-860c-50e4-a6eb-163acc450e19
DOI: 10.1101/2021.07.20.453104

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