Article

Rapid evolution of the human mutation spectrum

2016-10-30

Abstract excerpt

DNA is a remarkably precise medium for copying and storing biological information. This high fidelity results from the action of hundreds of genes involved in replication, proofreading, and damage repair. Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts. Consistent with this, usi...

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Literature Corpus work: ad2ee380-7af6-5e97-89c9-9b8e12ca1dee
DOI: 10.1101/084343

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