Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.

Abstract excerpt

Mutation spectra vary across genetic and environmental contexts, leading to differences between and within species. Most research on mutation spectrum has focused on trinucleotide (3-mer) mutation types in mammals, limiting the breadth and depth of variation surveyed. In this study, we use whole-genome resequencing data across 108 eukaryotic species-including mammals, fish, plants, and invertebrates-to...

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