Article
Impact of DNA physical properties on local sequence bias of human mutation.
Human mutation - 1 Dec 2010
Nakken Sigve, Rødland Einar A, Hovig Eivind
Abstract excerpt
In selectively neutral regions of the human genome, nucleotide substitutions do not occur at random with respect to the local DNA sequence neighborhood. However, apart from the hypermutability of methylated CpG dinucleotides, which can explain the overrepresentation of nucleotide transitions in this context, the sequence-specific factors underlying point mutation bias remain largely to be determined, both in...
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