Article

Sequence context and methylation interact to shape germline mutation rate variation at CpG sites

2025-11-13

Abstract excerpt

A prominent example of sequence context-dependent mutation rate variation is the elevated transition rate at CpG sites, which is largely attributed to cytosine methylation. CpGs with different flanking sequences also exhibit mutation rate variation, but this variation is only partially correlated with context-specific methylation level. Here, we quantify the CpG mutation rate and mutagenic effect of methylation ac...

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Literature Corpus work: c2f8f995-b8cb-5791-a730-db4f1d5b1a0a
DOI: 10.1101/2025.11.13.688199

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