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Article

How Sequence Context-Dependent Mutability Drives Mutation Rate Variation in the Genome.

Genome biology and evolution - 2 Mar 2022

Oman Madeleine, Alam Aqsa, Ness Rob W

Abstract excerpt

The rate of mutations varies >100-fold across the genome, altering the rate of evolution, and susceptibility to genetic diseases. The strongest predictor of mutation rate is the sequence itself, varying 75-fold between trinucleotides. The fact that DNA sequence drives its own mutation rate raises a simple but important prediction; highly mutable sequences will mutate more frequently and eliminate themselves in...

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PMID: 35218359
DOI: 10.1093/gbe/evac032
PMCID: PMC8920511

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