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Article

Cumulative effect of COMT and 5-HTTLPR polymorphisms and their interaction with disease severity and comorbidities on the risk of psychosis in Alzheimer disease.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Apr 2006

Borroni Barbara, Grassi Mario, Agosti Chiara, Archetti Silvana, Costanzi Chiara, Cornali Cristina, Caltagirone Carlo, Caimi Luigi, Di Luca Monica, Padovani Alessandro

Abstract excerpt

OBJECTIVE: The objective of this study was to investigate the cumulative effect of the genes likely involved in Alzheimer disease (AD)-related psychosis and their interaction with disease stage and environmental factors. METHODS: Two hundred thirty-four patients with AD underwent clinical and neuropsychologic examination, behavioral and psychiatric disturbances evaluation, and were subsequently divided into two...

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Source

Identifiers

PMID: 16582043
DOI: 10.1097/01.JGP.0000192491.50802.c3

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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