Article
Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.
Neurobiology of aging - 1 Aug 2007
Borroni B, Grassi M, Costanzi C, Zanetti M, Archetti S, Franzoni S, Caimi L, Padovani A
Abstract excerpt
BACKGROUND: The gene encoding catechol-O-methyltransferase (COMT) has been suggested as a candidate for Alzheimer-related psychosis (AD-P) susceptibility, and an association between AD-P and a functional valine to methionine polymorphism has been reported. OBJECTIVE: The aim of this study was to assess the genetic contribution of other COMT variants to the risk of AD-P. METHODS: Two hundred and forty-six AD...
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