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Article

Role of BRCA1 in brain development.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2014

Pao Gerald M, Zhu Quan, Perez-Garcia Carlos G, Chou Shen-Ju, Suh Hoonkyo, Gage Fred H, O'Leary Dennis D M, Verma Inder M

Abstract excerpt

Breast cancer susceptibility gene 1 (BRCA1) is a breast and ovarian cancer tumor suppressor whose loss leads to DNA damage and defective centrosome functions. Despite its tumor suppression functions, BRCA1 is most highly expressed in the embryonic neuroepithelium when the neural progenitors are highly proliferative. To determine its functional significance, we deleted BRCA1 in the developing brain using a neural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24639535
DOI: 10.1073/pnas.1400783111
PMCID: PMC3977248

Genes

BRCA1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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