Article

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis

2022-08-18

Abstract excerpt

Medulloblastoma (MB) is the most common malignant childhood brain tumor 1,2 , yet the origin of the most aggressive subgroup-3 form remains elusive, impeding development of effective targeted treatments. Previous analyses of mouse cerebella 3,4 or human counterparts from frozen tissue nuclei 5 have not fully defined the compositional heterogeneity of MBs. Here, we undertook an unprecedented single-cell profilin...

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Literature Corpus work: 9ed15947-9b8c-5d15-8026-96acfdf13c82
DOI: 10.1101/2022.08.17.504304

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