Article

Single-cell RNA sequencing data reveals rewiring of transcriptional relationships in Alzheimer’s Disease associated with risk variants

2023-05-16

Abstract excerpt

<h4>ABSTRACT</h4> Understanding how genetic risk variants contribute to Alzheimer’s Disease etiology remains a challenge. Single-cell RNA sequencing (scRNAseq) allows for the investigation of cell type specific effects of genomic risk loci on gene expression. Using seven scRNAseq datasets totalling >1.3 million cells, we investigated differential correlation of genes between healthy individuals and individuals dia...

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Literature Corpus work: 830d9754-76da-5cd2-8c4c-011e41fed4c2
DOI: 10.1101/2023.05.15.23289992

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