Article

Targeting Siglec-10/α3β1 Integrin Interactions Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer

2025-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Tumor-associated macrophages (TAMs) in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) exhibit immunosuppressive phenotypes and impaired phagocytic activity, facilitating tumor progression and immune evasion. Here, we identify integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for Siglec-10, an inhibitory glyco-immune checkpoint rece...

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Literature Corpus work: c2dcaebd-4faf-5b3e-a99d-ad6b46f742f4
DOI: 10.1101/2025.05.06.652455

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