Article

Tumor-specific CD4 T cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma

2022-11-10

Abstract excerpt

<h4>Summary</h4> Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy resistant to immunotherapy. The pancreatic tumor microenvironment is shaped and maintained by myeloid cells that outnumber tumor cells. Here, using monocyte fate-mapping PDA mouse models and human tumor tissues, we identify monocytes give rise to most heterogeneous macrophage subpopulations in PDA. We show that monocyte differentiation...

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Literature Corpus work: 350319fa-0ab2-540b-a2df-5e3d52fdf8a6
DOI: 10.1101/2022.11.09.515858

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