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Article

α-Synuclein Decreases the Abundance of Proteasome Subunits and Alters Ubiquitin Conjugates in Yeast.

Cells - 28 Aug 2021

Popova Blagovesta, Galka Dajana, Häffner Nicola, Wang Dan, Schmitt Kerstin, Valerius Oliver, Knop Michael, Braus Gerhard H

Abstract excerpt

Parkinson's disease (PD) is the most prevalent movement disorder characterized with loss of dopaminergic neurons in the brain. One of the pathological hallmarks of the disease is accumulation of aggregated α-synuclein (αSyn) in cytoplasmic Lewy body inclusions that indicates significant dysfunction of protein homeostasis in PD. Accumulation is accompanied with highly elevated S129 phosphorylation, suggesting that...

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PMID: 34571878
DOI: 10.3390/cells10092229
PMCID: PMC8468666

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