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Article

Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Nov 2011

Sato Hiroyasu, Arawaka Shigeki, Hara Susumu, Fukushima Shingo, Koga Kaori, Koyama Shingo, Kato Takeo

Abstract excerpt

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra (SN) and the appearance of fibrillar aggregates of insoluble α-synuclein (α-syn) called Lewy bodies (LBs). Approximately 90% of α-syn deposited in LBs is phosphorylated at serine 129 (Ser129). In contrast, only 4% of total α-syn is phosphorylated in normal brain, suggesting that accumulation of...

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Identifiers

PMID: 22090514
DOI: 10.1523/JNEUROSCI.3967-11.2011
PMCID: PMC6633319

Genes

GRK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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