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Article

α-synuclein phosphorylation and truncation are normal events in the adult human brain.

Neuroscience - 3 Jan 2012

Muntané G, Ferrer I, Martinez-Vicente M

Abstract excerpt

α-synuclein is a key protein in Lewy body diseases (LBDs) and a major component of Lewy bodies and related aberrant cytoplasmic and neuritic inclusions. Regional differences in α-synuclein have been associated with selective neuronal vulnerability to Lewy pathology. Furthermore, phosphorylation at serine 129 (Ser129) and α-synuclein truncation have been considered crucial in the pathogenesis of Lewy inclusions....

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PMID: 22079575
DOI: 10.1016/j.neuroscience.2011.10.042

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