Article
Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.
The Journal of biological chemistry - 10 Apr 2015
Mbefo Martial Kamdem, Fares Mohamed-Bilal, Paleologou Katerina, Oueslati Abid, Yin Guowei, Tenreiro Sandra, Pinto Madalena, Outeiro Tiago, Zweckstetter Markus, Masliah Eliezer, Lashuel Hilal A
Abstract excerpt
Although α-synuclein (α-syn) phosphorylation has been considered as a hallmark of sporadic and familial Parkinson disease (PD), little is known about the effect of PD-linked mutations on α-syn phosphorylation. In this study, we investigated the effects of the A30P, E46K, and A53T PD-linked mutations on α-syn phosphorylation at residues Ser-87 and Ser-129. Although the A30P and A53T mutants slightly affected...
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