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Article

TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.

Cell - 3 Aug 2012

Zhong Franklin L, Batista Luis F Z, Freund Adam, Pech Matthew F, Venteicher Andrew S, Artandi Steven E

Abstract excerpt

Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal bodies, and telomerase is thought to be recruited to telomeres through interactions with telomere-binding proteins. Here, we show that the OB-fold domain of the telomere-binding protein TPP1 recruits tel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22863003
DOI: 10.1016/j.cell.2012.07.012
PMCID: PMC3516183

Genes

TPP1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22863003-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.PMID 22863003Read ↗

The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase ActionSemantic proximity Read ↗

Identification of human TERT elements necessary for telomerase recruitment to telomeres.Semantic proximity Read ↗

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.Semantic proximity Read ↗

Interaction hub critical for telomerase recruitment and primer-template handling for catalysis.Semantic proximity Read ↗

InTERTpreting telomerase structure and functionSemantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitmentSemantic proximity Read ↗

POT1-TPP1 telomere length regulation and diseaseSemantic proximity Read ↗

Complex interaction network revealed by mutation of human telomerase 'insertion in fingers' and essential N-terminal domains and the telomere protein TPP1.Semantic proximity Read ↗

OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length RegulationSemantic proximity Read ↗

CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.Semantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

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