Article

Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1

2018-04-10

Abstract excerpt

Telomere maintenance is essential for the long-term proliferation of human pluripotent stem cells, while their telomere length set point determines the proliferative capacity of their differentiated progeny. The shelterin protein TPP1 is required for telomere stability and elongation, but its role in set point establishment remains elusive. Here, we characterize the contribution of TPP1 isoforms and residues outsi...

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Literature Corpus work: d1ee8913-4473-5b80-aa96-a205ad32012f
DOI: 10.1101/298778

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