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Article

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2021

Sandhu Ranjodh, Sharma Madhav, Wei Derek, Xu Lifeng

Abstract excerpt

The shelterin protein TPP1 is involved in both recruiting telomerase and stimulating telomerase processivity in human cells. Assessing the in vivo significance of the latter role of TPP1 has been difficult, because TPP1 mutations that perturb telomerase function tend to abolish both telomerase recruitment and processivity. The Saccharomyces cerevisiae telomerase-associated Est3 protein adopts a protein fold...

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Identifiers

PMID: 34282008
DOI: 10.1073/pnas.2024889118
PMCID: PMC8325329

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The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment.PMID 34282008Read ↗

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