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Article

Identification of human TERT elements necessary for telomerase recruitment to telomeres.

eLife - 1 Oct 2014

Schmidt Jens C, Dalby Andrew B, Cech Thomas R

Abstract excerpt

Human chromosomes terminate in telomeres, repetitive DNA sequences bound by the shelterin complex. Shelterin protects chromosome ends, prevents recognition by the DNA damage machinery, and recruits telomerase. A patch of amino acids, termed the TEL-patch, on the OB-fold domain of the shelterin component TPP1 is essential to recruit telomerase to telomeres. In contrast, the site on telomerase that interacts with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25271372
DOI: 10.7554/eLife.03563
PMCID: PMC4359370

Genes

TPP1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Identification of human TERT elements necessary for telomerase recruitment to telomeres.PMID 25271372Read ↗

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.Semantic proximity Read ↗

Interaction hub critical for telomerase recruitment and primer-template handling for catalysis.Semantic proximity Read ↗

TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.Semantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment.Semantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitmentSemantic proximity Read ↗

The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase ActionSemantic proximity Read ↗

Structural and functional consequences of a disease mutation in the telomere protein TPP1.Semantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivitySemantic proximity Read ↗

Quantitative Biology of Human Shelterin and Telomerase: Searching for the Weakest PointSemantic proximity Read ↗

Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations.Semantic proximity Read ↗

Characterization of novel mutations in the TEL-patch domain of the telomeric factor TPP1 associated with telomere biology disorders.Semantic proximity Read ↗

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