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Proton motive force mediated efflux mismatch drives gentamycin-novobiocin collateral sensitivity in Pseudomonas aeruginosa

2026-05-05

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Resistance to a particular antibiotic can make bacteria sensitive to others, a phenomenon known as collateral sensitivity (CS). This study explored potential CS in clinical and experimentally evolved drug-resistant Pseudomonas aeruginosa (PA) and investigated underlying mechanisms. Whole-genome sequencing and RNA-seq were analyzed to identify genetic and transcriptional correlations. In vitro efficacies were ass...

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Literature Corpus work: 82c2d057-f7e4-562b-a6e5-69b24a529131
DOI: 10.64898/2026.05.01.722319

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Proton motive force mediated efflux mismatch drives gentamycin-novobiocin collateral sensitivity in <i>Pseudomonas aeruginosa</i>

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