Article

Robust antibiotic sensitization of pathogenic <i>Pseudomonas aeruginosa</i> via negative hysteresis in the cell envelope

2025-08-27

Abstract excerpt

Antibiotic combination in time and space is a key strategy to combat antimicrobial resistance. The success of such treatment designs requires their robust efficacy across treatment conditions and a pathogen’s genomic diversity. This study found that an initial treatment with a β-lactam antibiotic causes robust cellular sensitization towards an aminoglycoside antibiotic across the high-risk human pathogen Pseudomo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bf554b5e-bb3a-5754-b51a-313c3fb8596c
DOI: 10.1101/2025.08.22.671355

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust antibiotic sensitization of pathogenic <i>Pseudomonas aeruginosa</i> via negative hysteresis in the cell envelopeDOI 10.1101/2025.08.22.671355Read

Navigating collateral sensitivity: insights into the mechanisms and applications of antibiotic resistance trade-offsSemantic proximity Read

Heterogeneity during induction of resistance delays <i>Pseudomonas aeruginosa</i> recovery from antibiotic exposuresSemantic proximity Read

In vitro exposure to non-antipseudomonal antibiotics (NAPA) induces <i>Pseudomonas aeruginosa</i> resistance to antipseudomonal antibiotics (APA)Semantic proximity Read

Proton motive force mediated efflux mismatch drives gentamycin-novobiocin collateral sensitivity in <i>Pseudomonas aeruginosa</i>Semantic proximity Read

Evolutionary stability of collateral sensitivity to antibiotics in the model pathogen <i>Pseudomonas aeruginosa</i>Semantic proximity Read

A combination of phenotypic responses and genetic adaptations enables <i>Staphylococcus aureus</i> to withstand inhibitory molecules secreted by <i>Pseudomonas aeruginosa</i>Semantic proximity Read

Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosisSemantic proximity Read

Carbapenem-resistance <i>oprD</i> mutations reshape <i>Pseudomonas aeruginosa</i> host-pathogen interactions during infectionSemantic proximity Read

Evolution of Antibiotic Tolerance Shapes Resistance Development in Chronic Pseudomonas aeruginosa Infections.Semantic proximity Read

β-lactamase expression induces collateral sensitivity in <i>Escherichia coli</i>Semantic proximity Read

R-pyocin-mediated selection reverses pan-drug resistance in <i>Pseudomonas aeruginosa</i>Semantic proximity Read

High-level carbapenem tolerance requires antibiotic-induced outer membrane modificationsSemantic proximity Read