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Article

Collateral Sensitivity Interactions between Antibiotics Depend on Local Abiotic Conditions

30 Nov 2021

Abstract excerpt

When bacteria become resistant to an antibiotic, the genetic changes involved sometimes increase (cross-resistance) or decrease (collateral sensitivity) their resistance to other antibiotics. Antibiotic combinations showing repeatable collateral sensitivity could be used in treatment to slow resistance evolution. However, collateral sensitivity interactions may depend on the local environmental conditions that...

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Identifiers

PMID: 34846167
DOI: 10.1128/msystems.01055-21

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