Article
Bacterial evolution of antibiotic hypersensitivity.
Molecular systems biology - 29 Oct 2013
Lázár Viktória, Pal Singh Gajinder, Spohn Réka, Nagy István, Horváth Balázs, Hrtyan Mónika, Busa-Fekete Róbert, Bogos Balázs, Méhi Orsolya, Csörgő Bálint, Pósfai György, Fekete Gergely, Szappanos Balázs, Kégl Balázs, Papp Balázs, Pál Csaba
Abstract excerpt
The evolution of resistance to a single antibiotic is frequently accompanied by increased resistance to multiple other antimicrobial agents. In sharp contrast, very little is known about the frequency and mechanisms underlying collateral sensitivity. In this case, genetic adaptation under antibiotic stress yields enhanced sensitivity to other antibiotics. Using large-scale laboratory evolutionary experiments with...
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