Back to search

Article

High-level ciprofloxacin resistance in <i>Pseudomonas aeruginosa</i> is associated with genomic adaptation, collateral antibiotic susceptibility, and physiological trade-offs

2026-07-29

Abstract excerpt

Antimicrobial resistance in Pseudomonas aeruginosa has emerged as a major clinical concern. Ciprofloxacin has potent intrinsic activity against P. aeruginosa , but resistance to this antibiotic is increasingly reported in clinical settings. In this study, P. aeruginosa ATCC 27853 strain was exposed to gradually increasing ciprofloxacin concentrations for 50 passages (∼100 days). The final selected resistant str...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
065fa55f-f91c-5d22-b10f-8ed18e6552cf
DOI
10.64898/2026.07.29.741402
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
High-level ciprofloxacin resistance in <i>Pseudomonas aeruginosa</i> is associated with genomic adaptation, collateral antibiotic susceptibility, and physiological trade-offsDOI 10.64898/2026.07.29.741402
Qualitative analysis of genomic mutations and antibiotic susceptibility testing of Pseudomonas aeruginosa isolates from chronic lung infections.Semantic proximity
Keeping up with the pathogens: Improved antimicrobial resistance detection and prediction from<i>Pseudomonas</i>aeruginosa genomesSemantic proximity
A Panel of Diverse <i>Pseudomonas aeruginosa</i> Clinical Isolates for Research and DevelopmentSemantic proximity
Quantifying the contribution of four resistance mechanisms to ciprofloxacin minimum inhibitory concentration in <i>Escherichia coli</i> : a systematic reviewSemantic proximity
Correlation between phenotypic antibiotic susceptibility and the resistome in Pseudomonas aeruginosa.Semantic proximity
Genomic and phenotypic comparison of environmental and patient-derived isolates of <i>Pseudomonas aeruginosa</i> suggest that antimicrobial resistance is rare within the environmentSemantic proximity
Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility.Semantic proximity
Molecular determinants associated with resistance to imipenem and imipenem–relebactam in clinical Pseudomonas aeruginosa isolatesSemantic proximity
Comparative genome analysis of ciprofloxacin-resistant Pseudomonas aeruginosa reveals genes within newly identified high variability regions associated with drug resistance development.Semantic proximity
Gene-Gene Interactions Dictate Ciprofloxacin Resistance in Pseudomonas aeruginosa and Facilitate Prediction of Resistance Phenotype from Genome Sequence Data.Semantic proximity
Emergence of XDR high-risk <i>Pseudomonas aeruginosa</i> ST309 in South America: a global comparative genomic analysisSemantic proximity
A large-scale comparison shows that genetic changes causing antibiotic resistance in experimentally evolved <i>Pseudomonas aeruginosa</i> predict those in naturally evolved bacteriaSemantic proximity
Select a neighboring publication to make it the new centre.