Article

Cross-GWAS coherence test at the gene and pathway level

2021-05-19

Abstract excerpt

Proximal genetic variants are frequently correlated, implying that the corresponding effect sizes detected by genome-wide association studies (GWAS) are also not independent. Methods already exist to account for this when aggregating effects from a single GWAS across genes or pathways. Here we present a rigorous yet fast method for detecting genes with coherent association signals for two traits, facilitating cros...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82b3d484-b9df-5d5e-bd77-489526e160f4
DOI: 10.1101/2021.05.16.21257289

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross-GWAS coherence test at the gene and pathway levelDOI 10.1101/2021.05.16.21257289Read

Cross-GWAS coherence test at the gene and pathway level.Semantic proximity Read

Statistical co-analysis of high-dimensional association studiesSemantic proximity Read

mBAT-combo: a more powerful test to detect gene-trait associations from GWAS dataSemantic proximity Read

mBAT-combo: A more powerful test to detect gene-trait associations from GWAS data.Semantic proximity Read

Multitrait genetic-phenotype associations to connect disease variants and biological mechanismsSemantic proximity Read

Genome-wide gene and pathway analysis.Semantic proximity Read

Dissecting the colocalized GWAS and eQTLs with mediation analysis for high-dimensional exposures and confounders.Semantic proximity Read

A powerful and versatile colocalization test.Semantic proximity Read

A Powerful Method for Pleiotropic Analysis under Composite Null Hypothesis Identifies Novel Shared Loci Between Type 2 Diabetes and Prostate CancerSemantic proximity Read

Phenotype-resolved cis-eQTL Mendelian Randomization and Colocalization Prioritize MAPK3 and UQCC1 in Two Selected Osteoarthritis Candidate RegionsSemantic proximity Read

Pathway and gene-based analysis of genome wide association studies (GWAS)Semantic proximity Read

An atlas connecting shared genetic architecture of human diseases and molecular phenotypes provides insight into COVID-19 susceptibilitySemantic proximity Read