Article

Persistent endotoxin exposure in macrophages elicits an immunometabolic profile susceptible to NF-κB and p53 perturbation

2025-05-07

Abstract excerpt

The prolonged exposure of macrophages to endotoxin occurs in various chronic inflammatory conditions, including long-term inflammation triggered by particle-releasing implanted biomaterials, progressive pulmonary obstructive conditions, chronic bronchitis, colitis and hepatitis characterized by sustained exposure to gut-derived lipopolysaccharide (LPS). However, immune cellular metabolism in models of persistent i...

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Literature Corpus work: 82a66951-1098-5632-b86d-66f3dbfecb89
DOI: 10.1101/2025.04.30.651567

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