Article

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation

2020-08-18

Abstract excerpt

Oxylipins are potent biological mediators requiring strict control, but how they are removed en masse during infection and inflammation is unknown. Here we show that lipopolysaccharide (LPS) dynamically enhances oxylipin removal via mitochondrial β-oxidation. Specifically, genetic or pharmacological targeting of carnitine palmitoyl transferase 1 (CPT1), a mitochondrial importer of fatty acids, reveal that many oxy...

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Literature Corpus work: 3dff5075-9cf2-5b4e-8a7f-7a3ac698fe89
DOI: 10.1101/2020.08.17.252007

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